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a procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain andor insufficient估计的过程随着时间的推移,场景的代谢通量测量不确定和或不足
BMC Bioinformatics BioMed Central
Methodology article Open Access
A procedure for the estimation over time of metabolic fluxes in
scenarios where measurements are uncertain and/or insufficient
Francisco Llaneras* and Jesús Picó
Address: Dept. of Systems Engineering and Control, Technical University of Valencia, Camino de Vera s/n, 46022 Valencia, Spain
Email: Francisco Llaneras* - frallaes@doctor.upv.es; Jesús Picó - jpico@ai2.upv.es
* Corresponding author
Published: 30 October 2007 Received: 24 May 2007
Accepted: 30 October 2007
BMC Bioinformatics 2007, 8:421 doi:10.1186/1471-2105-8-421
This article is available from: /1471-2105/8/421
© 2007 Llaneras and Picó; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: An indirect approach is usually used to estimate the metabolic fluxes of an organism:
couple the available measurements with known biological constraints (e.g. stoichiometry). Typically
this estimation is done under a static point of view. Therefore, the fluxes so obtained are only valid
while the environmental conditions and the cell state remain stable. However, estimating the
evolution over time of the metabolic fluxes is valuable to investigate the dynamic behaviour of an
organism and also t
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