原创力文档a study protocol to evaluate the relationship between outdoor air pollution and pregnancy outcomes研究协议评估室外空气污染和妊娠结局的关系.pdfVIP
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a study protocol to evaluate the relationship between outdoor air pollution and pregnancy outcomes研究协议评估室外空气污染和妊娠结局的关系
Ribeiro et al. BMC Public Health 2010, 10:613
/1471-2458/10/613
STUDY PROTOCOL Open Access
A study protocol to evaluate the relationship
between outdoor air pollution and pregnancy
outcomes
1* 1 1 2 2 2
Manuel C Ribeiro , Maria J Pereira , Amílcar Soares , Cristina Branquinho , Sofia Augusto , Esteve Llop ,
Susana Fonseca3 3 4 5 6 7
, Joaquim G Nave , António B Tavares , Carlos M Dias , Ana Silva , Ismael Selemane ,
8 8 6
Joaquin de Toro , Mário J Santos , Fernanda Santos
Abstract
Background: The present study protocol is designed to assess the relationship between outdoor air pollution and
low birth weight and preterm births outcomes performing a semi-ecological analysis. Semi-ecological design
studies are widely used to assess effects of air pollution in humans. In this type of analysis, health outcomes and
covariates are measured in individuals and exposure assignments are usually based on air quality monitor stations.
Therefore, estimating individual exposures are one of the major challenges when investigating these relationships
with a semi-ecologic design.
Methods/Design: Semi-ecologic study consisting of a retrospective cohort study with ecologic assignment of
exposure is applied. Health outcomes and covariates are collected at Primary Health Care Center. Data from
pregnant registry, clinical record and specific questionnaire administered orally to the mothers of children born in
period 2007-2010 in Portuguese Alentejo Litoral region, are collected by the research team. Outdoor air pollution
data are collected wi
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