原创力文档aacr special conference snps, haplotypes, and cancer – applications in molecular epidemiology, key biscayne, florida, usa, 13–17 september 2003aacr特别会议单核苷酸多态性、单体型和癌症u2014u2014应用在分子流行病学,比斯坎湾,佛罗里达,美国2003年9月.pdfVIP
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aacr special conference snps, haplotypes, and cancer – applications in molecular epidemiology, key biscayne, florida, usa, 13–17 september 2003aacr特别会议单核苷酸多态性、单体型和癌症u2014u2014应用在分子流行病学,比斯坎湾,佛罗里达,美国2003年9月
Available online /content/6/2/E9
Meeting report
AACR Special Conference: SNPs, haplotypes, and cancer –
applications in molecular epidemiology, Key Biscayne, Florida,
USA, 13–17 September 2003
David G Cox
Department of Epidemiology and Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Corresponding author: David G Cox (e-mail: dcox@)
Published: 18 December 2003
Breast Cancer Res 2004, 6:E9 (DOI 10.1186/bcr756)
© 2004 BioMed Central Ltd (Print ISSN 1465-5411; Online ISSN 1465-542X)
Abstract
This American Association for Cancer Research Special Conference brought together scientists with
diverse expertise to address issues related to use of appropriate epidemiological, statistical, and
laboratory methods to study the genetic epidemiology of cancer. Discussions focused on experiences
with association studies using single nucleotide polymorphisms and haplotypes, their limitations, and
what is needed to improve on the current ‘state of the art’. Various studies were presented in different
contexts, ranging from candidate gene studies to whole genome scans, and conducted in prospective
cohorts, case–control studies, and other study designs. Common problems such as determining the
probability that observed associations are false negative or false positive, the potential effects of
admixture, and determining which polymorphisms to examine in which genes and in which populations
were examined. Problems specific to haplotype analysis were discussed, with emphasis on haplotype
block structures and on how to use haplotypes in analysis. Questions were also pose
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