ab initio and homology based prediction of protein domains by recursive neural networks从头开始和基于同源性的预测蛋白质域的递归神经网络.pdfVIP
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ab initio and homology based prediction of protein domains by recursive neural networks从头开始和基于同源性的预测蛋白质域的递归神经网络
BMC Bioinformatics BioMed Central
Research article Open Access
Ab initio and homology based prediction of protein domains by
recursive neural networks
Ian Walsh1,2, Alberto JM Martin1,2, Catherine Mooney1,2, Enrico Rubagotti1,2,
Alessandro Vullo 1,2 and Gianluca Pollastri*1,2
Address: 1School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland and 2Complex and Adaptive Systems
Laboratory, University College Dublin, Belfield, Dublin 4, Ireland
Email: Ian Walsh - ian.walsh@ucd.ie; Alberto JM Martin - albertoj@ucd.ie; Catherine Mooney - catherine.mooney@ucd.ie;
Enrico Rubagotti - enrico.rubagotti@ucd.ie; Alessandro Vullo - alessandro.vullo@ucd.ie; Gianluca Pollastri* - gianluca.pollastri@ucd.ie
* Corresponding author
Published: 26 June 2009 Received: 17 October 2008
Accepted: 26 June 2009
BMC Bioinformatics 2009, 10:195 doi:10.1186/1471-2105-10-195
This article is available from: /1471-2105/10/195
© 2009 Walsh et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Proteins, especially larger ones, are often composed of individual evolutionary units, domains,
which have their own function and structural fold. Predicting domains is an important intermediate step in protein
analyses, including the prediction of protein structures.
Results: We describe novel systems f
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