ab initio and homology based prediction of protein domains by recursive neural networks从头开始和基于同源性的预测蛋白质域的递归神经网络.pdfVIP

ab initio and homology based prediction of protein domains by recursive neural networks从头开始和基于同源性的预测蛋白质域的递归神经网络.pdf

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ab initio and homology based prediction of protein domains by recursive neural networks从头开始和基于同源性的预测蛋白质域的递归神经网络

BMC Bioinformatics BioMed Central Research article Open Access Ab initio and homology based prediction of protein domains by recursive neural networks Ian Walsh1,2, Alberto JM Martin1,2, Catherine Mooney1,2, Enrico Rubagotti1,2, Alessandro Vullo 1,2 and Gianluca Pollastri*1,2 Address: 1School of Computer Science and Informatics, University College Dublin, Belfield, Dublin 4, Ireland and 2Complex and Adaptive Systems Laboratory, University College Dublin, Belfield, Dublin 4, Ireland Email: Ian Walsh - ian.walsh@ucd.ie; Alberto JM Martin - albertoj@ucd.ie; Catherine Mooney - catherine.mooney@ucd.ie; Enrico Rubagotti - enrico.rubagotti@ucd.ie; Alessandro Vullo - alessandro.vullo@ucd.ie; Gianluca Pollastri* - gianluca.pollastri@ucd.ie * Corresponding author Published: 26 June 2009 Received: 17 October 2008 Accepted: 26 June 2009 BMC Bioinformatics 2009, 10:195 doi:10.1186/1471-2105-10-195 This article is available from: /1471-2105/10/195 © 2009 Walsh et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Proteins, especially larger ones, are often composed of individual evolutionary units, domains, which have their own function and structural fold. Predicting domains is an important intermediate step in protein analyses, including the prediction of protein structures. Results: We describe novel systems f

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