原创力文档a study of smad4, smad6 and smad7 in surgically resected samples of pancreatic ductal adenocarcinoma and their correlation with clinicopathological parameters and patient survival研究smad4 smad6和胰腺导管腺癌的手术切除标本smad7及其与临床病理的相关性参数和患者生存.pdfVIP
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a study of smad4, smad6 and smad7 in surgically resected samples of pancreatic ductal adenocarcinoma and their correlation with clinicopathological parameters and patient survival研究smad4 smad6和胰腺导管腺癌的手术切除标本smad7及其与临床病理的相关性参数和患者生存
Singh et al. BMC Research Notes 2011, 4:560
/1756-0500/4/560
RESEARCH ARTICLE Open Access
A study of Smad4, Smad6 and Smad7 in
Surgically Resected Samples of Pancreatic Ductal
Adenocarcinoma and Their Correlation with
Clinicopathological Parameters and Patient
Survival
1* 2 1 3
Puneet Singh , Radhika Srinivasan , Jai Dev Wig and Bishan Das Radotra
Abstract
Background: Smad4 is the common mediator of the tumor suppressive functions of TGF-beta. Smad6 and Smad7
are the antagonists of the TGF-beta pathway. This study investigates the differential protein expressions of Smad4,
Smad6 and Smad7 in tumor as compared to normal tissue of pancreatic ductal adenocarcinoma (PDAC) and
compares them with clinicopathological parameters and patient survival.
Results: There was a significant difference in protein expressions of Smad4 (p = 0.0001), Smad6 (p = 0.0015) and
Smad7 (p = 0.0005) protein in tumor as compared to paired normal samples. Loss of Smad7 expression correlated
significantly with tumor size (r = 0.421, p 0.036) and margin status (r = 0.431; p .032). Patients with moderate
to high Smad4 protein expression had a better survival (median survival = 14.600 ± 2.112 months) than patients
with absent or weak Smad4 protein expression (median survival = 7.150 ± 0.662). In addition, advanced disease
stage correlated significantly with poor prognosis.
Conclusion: Loss of Smad4 significantly correlated with poor survival of PDAC patients. In the cases where Smad4
is expressed, Smad6 inhibition is possibly a novel mechanism for Smad4 inactivation. Smad7 has a role in
pathobiology of PDAC. Further investigation in the roles of Smad6 and Smad7 would help in the identification of
novel therapeutic targets for PDAC.
Keywords: Pancreas, pan
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