a study protocol for the evaluation of occupational mutageniccarcinogenic risks in subjects exposed to antineoplastic drugs a multicentric project研究协议职业mutageniccarcinogenic风险评估受试者暴露于抗肿瘤的药物一个多中心的项目.pdfVIP
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a study protocol for the evaluation of occupational mutageniccarcinogenic risks in subjects exposed to antineoplastic drugs a multicentric project研究协议职业mutageniccarcinogenic风险评估受试者暴露于抗肿瘤的药物一个多中心的项目
Moretti et al. BMC Public Health 2011, 11:195
/1471-2458/11/195
STUDY PROTOCOL Open Access
A study protocol for the evaluation of occupational
mutagenic/carcinogenic risks in subjects exposed
to antineoplastic drugs: a multicentric project
1 2 3 4 5 6
Massimo Moretti , Roberta Bonfiglioli , Donatella Feretti , Sofia Pavanello , Francesca Mussi , Maria G Grollino ,
1 2 3 4 5 6
Milena Villarini , Anna Barbieri , Elisabetta Ceretti , Mariella Carrieri , Annamaria Buschini , Massimo Appolloni ,
1 2 3 4 5 6
Luca Dominici , Laura Sabatini , Umberto Gelatti , Giovanni B Bartolucci , Paola Poli , Laura Stronati ,
Giuseppe Mastrangelo4 and Silvano Monarca1*
Abstract
Background: Some industrial hygiene studies have assessed occupational exposure to antineoplastic drugs; other
epidemiological investigations have detected various toxicological effects in exposure groups labeled with the job
title. In no research has the same population been studied both environmentally and epidemiologically. The
protocol of the epidemiological study presented here uses an integrated environmental and biological monitoring
approach. The aim is to assess in hospital nurses preparing and/or administering therapy to cancer patients the
current level of occupational exposure to antineoplastic drugs, DNA and chromosome damage as cancer predictive
effects, and the association between the two.
Methods/Design: About 80 healthy non-smoking female nurses, who job it is to prepare or handle antineoplastic
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