原创力文档abalone visceral extract inhibit tumor growth and metastasis by modulating cox-2 levels and cd8+ t cell activity鲍鱼内脏提取抑制肿瘤生长和转移的调制cox - 2水平和cd8 + t细胞的活动.pdfVIP
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abalonevisceralextractinhibittumorgrowthandmetastasisbymodulatingcox-2levelsandcd8tcellactivity鲍鱼内脏提取抑制肿瘤生长和转移的调制cox-2水平和cd8t细胞的活动
Lee et al. BMC Complementary and Alternative Medicine 2010, 10:60
/1472-6882/10/60
RESEARCH ARTICLE Open Access
Abalone visceral extract inhibit tumor growth and
metastasis by modulating Cox-2 levels and CD8+
T cell activity
1 1 1 1 2 1 1*
Choong-Gu Lee , Ho-Keun Kwon , Jae Ha Ryu , Sung Jin Kang , Chang-Rok Im , Jae II Kim , Sin-Hyeog Im
Abstract
Background: Abalone has long been used as a valuable food source in East Asian countries. Although the
nutritional importance of abalone has been reported through in vitro and in vivo studies, there is little evidence
about the potential anti-tumor effects of abalone visceral extract. The aim of the present study is to examine anti-
tumor efficacy of abalone visceral extract and to elucidate its working mechanism.
Methods: In the present study, we used breast cancer model using BALB/c mouse-derived 4T1 mammary
carcinoma and investigated the effect of abalone visceral extract on tumor development. Inhibitory effect against
tumor metastasis was assessed by histopathology of lungs. Cox-2 productions by primary and secondary tumor
were measured by real-time RT-PCR and immunoblotting (IB). Proliferation assay based on [3H]-thymidine
incorporation and measurement of cytokines and effector molecules by RT-PCR were used to confirm tumor
suppression efficacy of abalone visceral extract by modulating cytolytic CD8+ T cells. The cytotoxicity of CD8+ T
cell was compared by JAM test.
Results: Oral administration of abalone visceral extract reduced tumor growth (tumor volume and weight) and
showed reduced metastasis as confirmed by decreased level of splenomegaly (spleen size and weight) and
histological analysis of the lung metastasis (gross analysis and histologi
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