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aberrant activation of notch signalling in human breast cancer异常激活notch信号在人类乳腺癌
Available online /supplements/8/S2
Breast Cancer Research Volume 8 Supplement 2, November 2006
Meeting abstracts
Breast cancer research: the past and the future
The Royal Society, London, UK
1 November 2006
Published online: 1 November 2006
© 2006 BioMed Central Ltd
Keynote lectures Speaker abstracts
S1 S4
Breast cancer susceptibility after BRCA1/2: finding BRCA1 transcriptionally regulates genes associated
the genes and potential practical applications with the basal breast cancer phenotype
BAJ Ponder, AM Dunning, DF Easton, PDP Pharoah JE Quinn, CR James, JJ Gorskii, PB Mullan, DP Harkin
Strangeways Research Laboratories, Departments of Oncology and
Centre for Cancer Research and Cell Biology, Queen’s University
Public Health, University of Cambridge, UK
Belfast, Belfast City Hospital, Belfast, UK
Breast Cancer Research 2006, 8(Suppl 2):S1 (DOI 10.1186/bcr1544)
Breast Cancer Research 2006, 8(Suppl 2):S4 (DOI 10.1186/bcr1547)
Background Epidemiological studies have shown that only about 20%
of the familial clustering of breast cancer is explained by the known Background Ten to twenty per cent of breast tumours exhibit a basal-
highly penetrant mutations in BRCA1 and BCRA2. We have set out to like genetic profile and these tumours carry a poor prognosis. Breast
search for the genes for the remaining 80%. Twin studies indicate
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