原创力文档abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive腹部肥胖与一般肥胖识别动脉硬化、亚临床动脉粥样硬化和波反射在健康、糖尿病和高血压.pdfVIP
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abdominal obesity vs general obesity for identifying arterial stiffness, subclinical atherosclerosis and wave reflection in healthy, diabetics and hypertensive腹部肥胖与一般肥胖识别动脉硬化、亚临床动脉粥样硬化和波反射在健康、糖尿病和高血压
Recio-Rodriguez et al. BMC Cardiovascular Disorders 2012, 12:3
/1471-2261/12/3
RESEARCH ARTICLE Open Access
Abdominal obesity vs general obesity for
identifying arterial stiffness, subclinical
atherosclerosis and wave reflection in healthy,
diabetics and hypertensive
1* 1 2 1
Jose I Recio-Rodriguez , Manuel A Gomez-Marcos , Maria C Patino-Alonso , Cristina Agudo-Conde ,
1 1
Emiliano Rodriguez-Sanchez and Luis Garcia-Ortiz , for the Vasorisk group
Abstract
Background: Our aim was to analyze the relationship between abdominal obesity and general obesity, with
subclinical atherosclerosis, arterial stiffness and wave reflection in healthy, diabetics and hypertensive subjects.
Methods: A cross-sectional descriptive study was made of 305 individuals (diabetics 32.8%, hypertensive subjects
37.0% and healthy individuals 30.2%). Measurements: Body mass index (BMI), waist circumference (WC), body fat
percentage (BFP) and waist/height ratio (WHtR). Arterial stiffness was assessed according to pulse wave velocity
(PWV), intima-media thickness of the common carotid artery (C-IMT), augmentation index (central and peripheral),
ankle-brachial index (ABI), and central and peripheral pulse pressure.
Results: WC and WHtR showed a positive correlation to PWV and C-IMT in the studied groups. After adjusting for
age, gender, high sensitivity c-reactive protein, serum glucose and the presence of diabetes, hypertension,
smoking, dyslipidemia, antidiabetic drugs, lipid-lowering drugs, and atherosclerotic plaques, it was seen that for
every 0.1 point increase in WHtR, and for every cm increase in WC, the PWV increased 0.041 and 0.029 m/sec, and
C-IMT increased
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