原创力文档abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza a-associated ards腹部肥胖和长期容易定位的风险增加发展中硬化性胆管炎流感危重患者关联ards.pdfVIP
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abdominal obesity and prolonged prone positioning increase risk of developing sclerosing cholangitis in critically ill patients with influenza a-associated ards腹部肥胖和长期容易定位的风险增加发展中硬化性胆管炎流感危重患者关联ards
Weig et al. European Journal of Medical Research 2012, 17:30
/content/17/1/30 EUROPEAN JOURNAL
OF MEDICAL RESEARCH
RESEARCH Open Access
Abdominal obesity and prolonged prone
positioning increase risk of developing sclerosing
cholangitis in critically ill patients with influenza
A-associated ARDS
1† 2† 3 1 1 1
Thomas Weig , Mirjam I Schubert , Norbert Gruener , Michael E Dolch , Lorenz Frey , Jens Miller ,
Thorsten Johnson2 and Michael Irlbeck1*
Abstract
Background: Secondary sclerosing cholangitis is a severe disease of the biliary tract. Over the last decade, several
cases of sclerosing cholangitis in critically ill patients (SC-CIP) were reported. Reports in the literature so far are
characterized by a wide variety of underlying causes of critical illness, thereby hindering a risk-factor analysis. We
report on a homogenous cohort of critically ill patients with influenza A (H1N1) pneumonia and severe acute
respiratory distress syndrome (ARDS), of whom a subgroup developed sclerosing cholangitis, allowing for probing
of risk factors associated with SC-CIP.
Methods: Twenty-one patients (5 female, 16 male, 46.3 ± 10.8 years) with severe ARDS due to H1N1 pneumonia
were retrospectively divided into two groups, characterized by the presence (n = 5) and absence of SC-CIP (n = 16).
A large array of clinical data, laboratory parameters, and multi-detector computed tomography-derived measures
were compared.
Results: Both patient groups showed severe pulmonary impairment. Severity of disease on admission day and
during the first 14 d
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