原创力文档abdominal aortic calcification quantified by the morphological atherosclerotic calcification distribution (macd) index is associated with features of the metabolic syndrome腹主动脉钙化形态量化的动脉粥样硬化钙化分布(macd)指数与代谢综合征的特点相关联.pdfVIP
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abdominal aortic calcification quantified by the morphological atherosclerotic calcification distribution (macd) index is associated with features of the metabolic syndrome腹主动脉钙化形态量化的动脉粥样硬化钙化分布(macd)指数与代谢综合征的特点相关联
Barascuk et al. BMC Cardiovascular Disorders 2011, 11:75
/1471-2261/11/75
RESEARCH ARTICLE Open Access
Abdominal aortic calcification quantified by the
Morphological Atherosclerotic Calcification
Distribution (MACD) index is associated with
features of the metabolic syndrome
1*† 1,2† 1,2 3 4 1
Natasha Barascuk , Melanie Ganz , Mads Nielsen , Thomas C Register , Lars M Rasmussen , Morten A Karsdal
and Claus Christiansen1
Abstract
Background: Abdominal aortic calcifications (AAC) predict cardiovascular mortality. A new scoring model for AAC,
the Morphological Atherosclerotic Calcification Distribution (MACD) index may contribute with additional
information to the commonly used Aortic Calcification Severity (AC24) score, when predicting death from
cardiovascular disease (CVD). In this study we investigated associations of MACD and AC24 with traditional
metabolic-syndrome associated risk factors at baseline and after 8.3 years follow-up, to identify biological
parameters that may account for the differential performance of these indices.
Methods: Three hundred and eight healthy women aged 48 to 76 years, were followed for 8.3 ± 0.3 years. AAC
was quantified using lumbar radiographs. Baseline data included age, weight, blood pressure, blood lipids, and
glucose levels. Pearson correlation coefficients were used to test for relationships.
Results: At baseline and across all patients, MACD correlated with blood glucose (r2 = 0.1, P 0.001) and to a
lesser, but significant extent with traditional risk factors (p 0.01) of CVD. In the longitudinal analysis of correlations
between baseline biological parameters and the follow-up calcification assessment using radiographs we found
LDL-cholest
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