原创力文档a widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins普遍peroxiredoxin-like域存在于肿瘤抑制,progression-implicated蛋白质.pdfVIP
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a widespread peroxiredoxin-like domain present in tumor suppression- and progression-implicated proteins普遍peroxiredoxin-like域存在于肿瘤抑制,progression-implicated蛋白质
Pawłowski et al. BMC Genomics 2010, 11:590
/1471-2164/11/590
RESEARCH ARTICLE Open Access
A widespread peroxiredoxin-like domain present
in tumor suppression- and progression-implicated
proteins
2,4* 1 2 2 3 1*
Krzysztof Pawłowski , Anna Muszewska , Anna Lenart , Teresa Szczepińska , Adam Godzik , Marcin Grynberg
Abstract
Background: Peroxide turnover and signalling are involved in many biological phenomena relevant to human
diseases. Yet, all the players and mechanisms involved in peroxide perception are not known. Elucidating very
remote evolutionary relationships between proteins is an approach that allows the discovery of novel protein
functions. Here, we start with three human proteins, SRPX, SRPX2 and CCDC80, involved in tumor suppression and
progression, which possess a conserved region of similarity. Structure and function prediction allowed the
definition of P-DUDES, a phylogenetically widespread, possibly ancient protein structural domain, common to
vertebrates and many bacterial species.
Results: We show, using bioinformatics approaches, that the P-DUDES domain, surprisingly, adopts the
thioredoxin-like (Thx-like) fold. A tentative, more detailed prediction of function is made, namely, that of a 2-Cys
peroxiredoxin. Incidentally, consistent overexpression of all three human P-DUDES genes in two public
glioblastoma microarray gene expression datasets was discovered. This finding is discussed in the context of the
tumor suppressor role that has been ascribed to P-DUDES proteins in several studies. Majority of non-redundant P-
DUDES proteins are found in marine metagenome, and among the bacterial species possessing this domain a
trend for a higher proportion of aquatic species
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