additive risk survival model with microarray data添加剂风险生存与微阵列数据模型.pdfVIP

BMC Bioinformatics BioMed Central Methodology article Open Access Additive risk survival model with microarray data 1 2 Shuangge Ma* and Jian Huang Address: 1Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA and 2Department of Statistics and Actuarial Science, University of Iowa, Iowa City, IA 52242, USA Email: Shuangge Ma* - shuangge.ma@; Jian Huang - jian@ * Corresponding author Published: 8 June 2007 Received: 13 October 2006 Accepted: 8 June 2007 BMC Bioinformatics 2007, 8:192 doi:10.1186/1471-2105-8-192 This article is available from: /1471-2105/8/192 © 2007 Ma and Huang; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Microarray techniques survey gene expressions on a global scale. Extensive biomedical studies have been designed to discover subsets of genes that are associated with survival risks for diseases such as lymphoma and construct predictive models using those selected genes. In this article, we investigate simultaneous estimation and gene selection with right censored survival data and high dimensional gene expression measurements. Results: We model the survival