additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell linesibandronate添加剂生长抑制的影响和抗雌激素在雌激素受体阳性乳腺癌细胞系.pdfVIP
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additive growth inhibitory effects of ibandronate and antiestrogens in estrogen receptor-positive breast cancer cell linesibandronate添加剂生长抑制的影响和抗雌激素在雌激素受体阳性乳腺癌细胞系
Available online /content/8/1/R2
Vol 8 No 1 Open Access
Research article
Additive growth inhibitory effects of ibandronate and
antiestrogens in estrogen receptor-positive breast cancer cell
lines
1 1 2 3 4
Fabrice Journe , Carole Chaboteaux , Nicolas Magne , Hugues Duvillier , Guy Laurent and Jean-
Jacques Body1
1Laboratory of Endocrinology and Bone Diseases and Department of Internal Medicine, Institut J Bordet, Centre des Tumeurs de lUniversité Libre de
Bruxelles, Brussels, Belgium
2Department of Radiotherapy, Institut J Bordet, Centre des Tumeurs de lUniversité Libre de Bruxelles, Brussels, Belgium
3Laboratory of Experimental Hematology, Institut J Bordet, Centre des Tumeurs de lUniversité Libre de Bruxelles, Brussels, Belgium
4Laboratory of Histology, Faculty of Medicine and Pharmacy, Université de Mons-Hainaut, Mons, Belgium
Corresponding author: Jean-Jacques Body, jj.body@bordet.be
Received: 25 May 2005 Revisions requested: 28 Jul 2005 Revisions received: 14 Oct 2005 Accepted: 8 Nov 2005 Published: 12 Dec 2005
Breast Cancer Research 2006, 8:R2 (doi:10.1186/bcr1363)
This article is online at: /content/8/1/R2
© 2005 Journe et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Bisphosphonates are inhibitors of osteoclast- and IBEP-2 cells; 3 × 10-4 M for MDA-MB-231 cells), partly
mediated tumor-stimulated ost
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