原创力文档age modifies the genotype-phenotype relationship for the bitter receptor tas2r38年龄修改genotype-phenotype tas2r38苦味受体的关系.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
age modifies the genotype-phenotype relationship for the bitter receptor tas2r38年龄修改genotype-phenotype tas2r38苦味受体的关系
Mennella et al. BMC Genetics 2010, 11:60
/1471-2156/11/60
RESEARCH ARTICLE Open Access
Age modifies the genotype-phenotype
relationship for the bitter receptor TAS2R38
*
Julie A Mennella, M Yanina Pepino, Fujiko F Duke, Danielle R Reed
Abstract
Background: The purpose of this study was to investigate the effect of TAS2R38 haplotypes and age on human
bitter taste perception.
Results: Children (3 to 10 yrs), adolescents (11 to 19 yrs) and adults (mostly mothers, 20 to 55 yrs (N = 980) were
measured for bitter taste thresholds for 6-n-propylthiouracil (PROP) and genotyped for three polymorphisms of the
AS2R38 gene (A49P, V262A, I296V). Subjects were grouped by haplotype and age, as well as sex and race/ethnicity,
and compared for PROP thresholds. Subjects with the same haplotype were similar in bitter threshold regardless of
race/ethnicity (all ages) or sex (children and adolescents; all p-values 0.05) but age was a modifier of the
genotype-phenotype relationship. Specifically, AVI/PAV heterozygous children could perceive a bitter taste at lower
PROP concentrations than could heterozygous adults, with the thresholds of heterozygous adolescents being
intermediate (p 0.001). Similar age effects were not observed for subjects with the PAV/PAV or AVI/AVI
homozygous haplotypes (p 0.05) perhaps because there is less variation in taste perception among these
homozygotes.
Conclusions: These data imply that the change in PROP bitter sensitivity which occurs over the lifespan (from
bitter sensitive to less so) is more common in people with a particular haplotype combination, i.e., AVI/PAV
heterozygotes.
Background detect them at all [7,8]. Early family studies suggested
您可能关注的文档
- activities of colistin- and minocycline-based combinations against extensive drug resistant acinetobacter baumannii isolates from intensive care unit patients粘菌素的活动u2014u2014和minocycline-based组合对广泛耐药鲍曼不动杆菌分离株从重症监护室的病人.pdf
- activity and expression of urokinase-type plasminogen activator and matrix metalloproteinases in human colorectal cancer活动和表达urokinase-type纤溶酶原激活物和基质金属蛋白酶在人类结肠直肠癌.pdf
- activation of p38 mapk pathway in the skull abnormalities of apert syndrome fgfr2+p253r micep38 mapk通路的激活颅骨畸形的爱伯特综合症fgfr2 + p253r老鼠.pdf
- activity in geriatric acute care (agecar) rationale, design and methods活动在老年急性护理(agecar)原理,设计和方法.pdf
- activity of chemotherapy in mucinous ovarian cancer with a recurrence free interval of more than 6 months results from the socrates retrospective study活动的化疗粘液性卵巢癌复发免费间隔超过6个月的结果苏格拉底回顾性研究.pdf
- activity increase despite arthritis (a？da) design of a phase ii randomised controlled trial evaluating an active management booklet for hip and knee osteoarthritis [isrctn24554946]活动增加尽管关节炎( da)设计二期随机对照试验评估髋关节和膝关节骨关节炎的积极管理手册(isrctn24554946).pdf
- acupressure for smoking cessation – a pilot study按摩对戒烟u2014u2014一个试点研究.pdf
- activity of the acyl-coa synthetase acsl6 isoforms role of the fatty acid gate-domains酰基辅酶合成酶活性acsl6亚型脂肪酸gate-domains角色.pdf
- actos now for the prevention of diabetes (act now) study匹格列酮对于糖尿病的预防(act)的研究.pdf
- acupuncture and rehabilitation of the painful shoulder study protocol of an ongoing multicentre randomised controlled clinical trial [isrctn28687220]针灸治疗和康复的痛苦的肩膀研究协议的一个正在进行的多中心随机对照临床试验(isrctn28687220).pdf
- age trends in the prevalence of cervical squamous intraepithelial lesions among hiv-positive women in cameroon a cross-sectional study时代趋势在宫颈鳞状上皮内病变的患病率hiv呈阳性的妇女在喀麦隆一个横断面研究.pdf
- age differences in mental health literacy年龄的差异心理健康素养.pdf
- advertising and disclosure of funding on patient organisation websites a cross-sectional survey广告的资金和信息披露病人组织网站的横断面调查.pdf
- age- and sex-specific prevalence and ten-year risk for cardiovascular disease of all 16 risk factor combinations of the metabolic syndrome - a cross-sectional study年龄和性别患病率和十年的心血管疾病风险的所有16个风险因素组合代谢综合症u2014u2014一个横断面研究.pdf
- age, gender and disability predict future disability in older people the rotterdam study年龄、性别和残疾预测未来残疾老年人鹿特丹的研究.pdf
- age, chronic non-communicable disease and choice of traditional chinese and western medicine outpatient services in a chinese population年龄、慢性非传染性疾病和选择中西医在中国人口门诊服务.pdf
- age and sex dependent changes in liver gene expression during the life cycle of the rat年龄和性别相关的肝脏基因表达变化在老鼠的生命周期.pdf
- aged garlic extract therapy for sickle cell anemia patients陈大蒜汁治疗镰状细胞性贫血的病人.pdf
- age groups and spread of influenza implications for vaccination strategy年龄组和传播的流感疫苗接种策略的影响.pdf
- age-dependent induction of immunity and subsequent survival costs in males and females of a temperate damselfly年龄相关性免疫诱导和随后的生存成本温带豆娘的男性和女性.pdf
文档评论（0）