alternative initiation and splicing in dicer gene expression in human breast cells选择起始和拼接帽子在人类乳腺癌细胞基因表达.pdfVIP

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alternative initiation and splicing in dicer gene expression in human breast cells选择起始和拼接帽子在人类乳腺癌细胞基因表达.pdf

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alternative initiation and splicing in dicer gene expression in human breast cells选择起始和拼接帽子在人类乳腺癌细胞基因表达

Available online /content/7/4/R563 Vol 7 No 4 Open Access Research article Alternative initiation and splicing in dicer gene expression in human breast cells Charletha V Irvin-Wilson and Gautam Chaudhuri Division of Cancer Biology, Department of Biomedical Sciences, Meharry Medical College, Nashville, TN 37208, USA Corresponding author: Gautam Chaudhuri, gchaudhuri@ Received: 21 Dec 2004 Revisions requested: 7 Mar 2005 Revisions received: 25 Mar 2005 Accepted: 14 Apr 2005 Published: 16 May 2005 Breast Cancer Research 2005, 7:R563-R569 (DOI 10.1186/bcr1043) This article is online at: /content/7/4/R563 © 2005 Irvin-Wilson and Chaudhuri.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Dicer is a ribonuclease that mediates RNA alternative promoter selection along with alternative splicing of interference both at the transcriptional and the post- the 5-terminal exons apparently generate these variations. The transcriptional levels. Human dicer gene expression is regulated breast cell has at least two predominant forms of dicer mRNAs, in different tissues. Dicer is responsible for the synthesis of one of which has an additional 110 nucleotides at the 5-end. microRNAs and short temporal (st)RNAs that regulate the Sequence comparison revealed that the first 80 nucleotides of expression of many genes. Thus, understanding the control of these mRNA isoforms are encoded by