age-associated alterations in cxcl1 chemokine expression by murine b cells与年龄有关的变化处于由小鼠b细胞趋化因子表达.pdfVIP

BMC Immunology BioMed Central Research article Open Access Age-associated alterations in CXCL1 chemokine expression by murine B cells Lina Hu, Vishwa Deep Dixit, Valeria de Mello-Coelho and Dennis D Taub* Address: Laboratory of Immunology, Gerontology Research Center, National Institute on Aging-Intramural Research Program, National Institutes of Health, 5600 Nathan Shock Drive, Baltimore, MD 21224, USA Email: Lina Hu - lhu6@; Vishwa Deep Dixit - dixitvd@; Valeria de Mello-Coelho - coelhov@; Dennis D Taub* - taubd@ * Corresponding author Published: 26 July 2004 Received: 08 March 2004 Accepted: 26 July 2004 BMC Immunology 2004, 5:15 doi:10.1186/1471-2172-5-15 This article is available from: /1471-2172/5/15 © 2004 Hu et al; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. ChemokinesAgingLymphocytesB cellsimmunodeficiencyCXCL1 Abstract Background: The CXCL1 chemokines, macrophage inflammatory protein-2 (MIP-2) and cytokine-induced neutrophil chemoattractant (KC), have been shown to play a role in a number of pathophysiological disease states including endotoxin-induced inflammation and bacterial meningitis. While the expression of these chemokines has been identified in a variety of cell types in the mouse, litt