acute and chronic animal models for the evaluation of anti-diabetic agents急性和慢性动物模型的抗糖尿病药物的评价.pdfVIP

Kumar et al. Cardiovascular Diabetology 2012, 11:9 CARDIO /content/11/1/9 VASCULAR DIABETOLOGY REVIEW Open Access Acute and chronic animal models for the evaluation of anti-diabetic agents * Suresh Kumar , Rajeshwar Singh, Neeru Vasudeva and Sunil Sharma Abstract Diabetes mellitus is a potentially morbid condition with high prevalence worldwide thus being a major medical concern. Experimental induction of diabetes mellitus in animal models is essential for the advancement of our knowledge and understanding of the various aspects of its pathogenesis and ultimately finding new therapies and cure. Experimental diabetes mellitus is generally induced in laboratory animals by several methods that include: chemical, surgical and genetic (immunological) manipulations. Most of the experiments in diabetes are carried out in rodents, although some studies are still performed in larger animals. The present review highlights the various methods of inducing diabetes in experimental animals in order to test the newer drugs for their anti-diabetic potential. Keywords: Streptozotocin, alloxan, diabetic rats, animal models, diabetes Introduction in the regions dominated by developing economies. WHO reports Diabetes mellitus as one of the most According to the World Health Organization (WHO) common public health problems which will affect a total criteria, the prevalence of known diabetes was 5.6% and population of 220