原创力文档an interactive visualization tool to explore the biophysical properties of amino acids and their contribution to substitution matrices交互式可视化工具探讨氨基酸的生物物理特性及其对置换矩阵的贡献.pdfVIP
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an interactive visualization tool to explore the biophysical properties of amino acids and their contribution to substitution matrices交互式可视化工具探讨氨基酸的生物物理特性及其对置换矩阵的贡献
BMC Bioinformatics BioMed Central
Software Open Access
An interactive visualization tool to explore the biophysical
properties of amino acids and their contribution to substitution
matrices
1,2 1 2
Blazej Bulka , Marie desJardins and Stephen J Freeland*
Address: 1Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore,
MD 21250, USA and 2Department of Biological Sciences, University of Maryland, Baltimore County, 1000 Hilltop Circle, Baltimore, MD 21250,
USA
Email: Blazej Bulka - bulka1@; Marie desJardins - mariedj@; Stephen J Freeland* - freeland@
* Corresponding author
Published: 03 July 2006 Received: 12 December 2005
Accepted: 03 July 2006
BMC Bioinformatics 2006, 7:329 doi:10.1186/1471-2105-7-329
This article is available from: /1471-2105/7/329
© 2006 Bulka et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Quantitative descriptions of amino acid similarity, expressed as probabilistic models
of evolutionary interchangeability, are central to many mainstream bioinformatic procedures such
as sequence alignment, homology searching, and protein structural prediction. Here we present a
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