antimicrobial and toxicological activities of five medicinal plant species from cameroon traditional medicine抗菌素和毒理学活动五个药用植物物种来自喀麦隆的传统医学.pdfVIP

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2017-09-11 发布于上海
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antimicrobial and toxicological activities of five medicinal plant species from cameroon traditional medicine抗菌素和毒理学活动五个药用植物物种来自喀麦隆的传统医学.pdf

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antimicrobial and toxicological activities of five medicinal plant species from cameroon traditional medicine抗菌素和毒理学活动五个药用植物物种来自喀麦隆的传统医学

Assob et al. BMC Complementary and Alternative Medicine 2011, 11:70 /1472-6882/11/70 RESEARCH ARTICLE Open Access Antimicrobial and toxicological activities of five medicinal plant species from Cameroon Traditional Medicine 1* 2 3 2 3 1 Jules CN Assob , Henri LF Kamga , Dickson S Nsagha , Anna L Njunda , Peter F Nde , Emmanuel A Asongalem , Abdel J Njouendou4, Bertrand Sandjon5 and Veronique B Penlap6 Abstract Background: Infectious diseases caused by multiresistant microbial strains are on the increase. Fighting these diseases with natural products may be more efficacious. The aim of this study was to investigate the in vitro antimicrobial activity of methanolic, ethylacetate (EtOAc) and hexanic fractions of five Cameroonian medicinal plants (Piptadeniastum africana, Cissus aralioides, Hileria latifolia, Phyllanthus muellerianus and Gladiolus gregasius) against 10 pathogenic microorganisms of the urogenital and gastrointestinal tracts. Methods: The fractions were screened for their chemical composition and in vivo acute toxicity was carried out on the most active extracts in order to assess their inhibitory selectivity. The agar well-diffusion and the micro dilution methods were used for the determination of the inhibition diameters (ID) and Minimum inhibitory concentrations (MIC) respectively on 8 bacterial species including two Gram positive species (Staphylococcus aureus, Enterococcus faecalis), and six Gram negative (Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Proteus mirabilis, Shigella flexneri, Salmonella typhi) and two fungal isolates (Candida albicans, Candida krusei). The chemical composition was done according to Harbone (1976), the acute toxici