analysis of small nucleolar rnas reveals unique genetic features in malaria parasites小核仁的rna的分析,将揭示独特的遗传特征在疟疾寄生虫.pdfVIP
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analysis of small nucleolar rnas reveals unique genetic features in malaria parasites小核仁的rna的分析,将揭示独特的遗传特征在疟疾寄生虫
BMC Genomics BioMed Central
Research article Open Access
Analysis of small nucleolar RNAs reveals unique genetic features in
malaria parasites
Prakash Chandra Mishra, Anuj Kumar and Amit Sharma*
Address: Structural and Computational Biology Group, International Centre for Genetic Engineering and Biotechnology Aruna Asaf Ali Road, New
Delhi, 110067, India
Email: Prakash Chandra Mishra - pcm@icgeb.res.in; Anuj Kumar - k.anuj@; Amit Sharma* - amit.icgeb@
* Corresponding author
Published: 7 February 2009 Received: 3 June 2008
Accepted: 7 February 2009
BMC Genomics 2009, 10:68 doi:10.1186/1471-2164-10-68
This article is available from: /1471-2164/10/68
© 2009 Mishra et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Ribosome biogenesis is an energy consuming and stringently controlled process that
involves hundreds of trans-acting factors. Small nucleolar RNAs (snoRNAs), important
components of ribosome biogenesis are non-coding guide RNAs involved in rRNA processing,
nucleotide modifications like 2-O-ribose methylation, pseudouridylation and possibly gene
regulation. snoRNAs are ubiquitous and are diverse in their genomic organization, mechanism of
transcription and process of matur
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