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arabidopsis gene co-expression network and its functional modules拟南芥基因co-expression网络及其功能模块.pdf

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arabidopsis gene co-expression network and its functional modules拟南芥基因co-expression网络及其功能模块

BMC Bioinformatics BioMed Central Research article Open Access Arabidopsis gene co-expression network and its functional modules 1 2 1 Linyong Mao* , John L Van Hemert , Sudhansu Dash and Julie A Dickerson1,3 1 2 Address: Virtual Reality Applications Center, Iowa State University, Ames, IA 50010, USA, Program of Bioinformatics and Computational Biology, Iowa State University, Ames, IA 50010, USA and 3Department of Electrical and Computer Engineering, Iowa State University, Ames, IA 50010, USA Email: Linyong Mao* - linyongmao@; John L Van Hemert - jlv@; Sudhansu Dash - sdash@; Julie A Dickerson - julied@ * Corresponding author Published: 21 October 2009 Received: 31 March 2009 Accepted: 21 October 2009 BMC Bioinformatics 2009, 10:346 doi:10.1186/1471-2105-10-346 This article is available from: /1471-2105/10/346 © 2009 Mao et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Biological networks characterize the interactions of biomolecules at a systems-level. One important property of biological networks is the modular structure, in which nodes are densely con