原创力文档assessment of equine autoimmune thrombocytopenia (eat) by flow cytometry马的评估自身免疫性血小板减少症(吃)流式细胞术.pdfVIP
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assessment of equine autoimmune thrombocytopenia (eat) by flow cytometry马的评估自身免疫性血小板减少症(吃)流式细胞术
BMC Blood Disorders (2001) 1:1 /1471-2326/1/1
BMC Blood Disorders (2001) 1:1
Research article
Assessment of Equine Autoimmune Thrombocytopenia (EAT) by
flow cytometry
1,4 3 2
Rafael Nunez* , M. Alice Gomes-Keller , Colin Schwarzwald and Karsten
Feige2
Address: 1Institutes of Virology, University of Zurich, Zurich, Switzerland, 2Department of Internal Medicine, University of Zurich, Zurich,
Switzerland, 3Clinical Laboratory, University of Zurich, Zurich, Switzerland and 4Immunology Program, Memorial Sloan-Kettering Cancer
Center, New York, USA
E-mail: Rafael Nunez* - nunezr@; M. Alice Gomes-Keller - magomez@vetklinik.unizh.ch;
Colin Schwarzwald - schwarzw@vetklinik.unizh.ch; Karsten Feige - kfeige@vetklinik.unizh.ch
*Corresponding author
Published: 10 April 2001 Received: 15 November 2000
Accepted: 10 April 2001
BMC Blood Disorders 2001, 1:1
This article is available from: /1471-2326/1/1
(c) 2001 Nunez et al, licensee BioMed Central Ltd.
Abstract
Rationale: Thrombocytopenia is a platelet associated process that occurs in human and animals
as result of i) decreased production; ii) increased utilization; iii) increased destruction coupled to
the presence of antibodies, within a process know as immune-mediated thrombocytopenia (IMT);
or iv) platelet sequestration. Thus, the differentiation of the origin of IMT and the development of
reliable diagnostic approaches and methodologies are important in the clarification of IMT
pathogenesis. Therefore, there is a growing need in the field for easy to
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