association between egf +61 ga and glioma risk in a chinese population表皮生长因子+ 61 ga和神经胶质瘤的风险之间的联系在中国人口.pdfVIP

Wang et al. BMC Cancer 2010, 10:221 /1471-2407/10/221 R E S E A R C H A R T I C L E Open Access Research article Association between EGF +61 G/A and glioma risk in a Chinese population †2 1 3 3 4 5 3 Shujie Wang†1, Yao Zhao , Zhenchao Ruan , Hongyan Chen , Weiwei Fan , Juxiang Chen , Qihan Wu , Ji Qian , 6 1 3 Tianbao Zhang , Yan Huang* and Daru Lu* Abstract Background: Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variations of the EGF +61G/A (rs4444903) may lead to an alteration in EGF production and/or activity, which can result in individual susceptibility to brain glioma. The purpose of this study was to investigate the potential association between EGF +61G/A and brain glioma in a Chinese population. Methods: In this study, we analyzed single nucleotide polymorphism of EGF +61G/A in 677 patients with glioma and 698 gender- and age-matched controls. Genotyping was performed by polymerase chain reaction-ligation detection reaction (PCR-LDR) method. Results: The A allele (minor Allele) was 33.0% in cases and 27.3% in controls. The additive model was more powerful to reveal the association in our study than that of recessive and dominant model. Our data showed the genotype G/A and A/A was associated with increased risk for glioma (adjusted OR = 1.48, 95%CI: 1.17-1.87, p = 0.001 for G/A, adjusted OR = 1.81, 95%CI: 1.20-2.72, p = 0.005 for A/A, respectively), and for glioblastoma (adjusted OR = 1.51, 95%CI: 1.06-2.17, p = 0.024 and adjusted OR = 2.35, 95%CI: 1.34-4.15, p = 0.