原创力文档association between gefitinib and hemorrhagic cystitis and severely contracted bladder a case report吉非替尼和出血性膀胱炎,严重感染膀胱案例报告.pdfVIP
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association between gefitinib and hemorrhagic cystitis and severely contracted bladder a case report吉非替尼和出血性膀胱炎,严重感染膀胱案例报告
Arakawa et al. BMC Urology 2010, 10:6
/1471-2490/10/6
CASE REPORT Open Access
Association between gefitinib and hemorrhagic
cystitis and severely contracted bladder:
a case report
1 2* 2 3 2 1
Maki Arakawa , Kogenta Nakamura , Yoshiaki Yamada , Charles J Rosser , Motoi Tobiume , Hiroko Saito ,
Takaaki Hasegawa 1, Nobuaki Honda2
Abstract
Background: Gefitinib remains an excellent treatment option for patients with a variety of cancers, including non
small cell lung cancer (NSCLC). However, clinicians must be aware of the potential of gefitinib to cause an
inflammatory reaction in the skin, lungs and bladder.
Case Presentation: We present a case on hemorrhagic cystitis and severaly contracted bladder in a patient with
NSCLC on gefitinib.
Conclusions: Further studies are needed to substantiate the association of gefitinib therapy with hemorrhagic
cystitis and contracted bladder.
Background patient with NSCLC treated with gefitinib. The devel-
Epidermal growth factor receptor (EGFR) plays an opment of a severely contracted bladder can greatly
important role in the growth, development and pro- impede urine storage, which can have severe effects on
gression of non small cell lung cancer (NSCLC) [1]. quality of life, necessitating major urinary reconstruc-
Gefitinib (Iressa®) is an oral selective inhibitor of EGFR tive surgery.
tyrosine kinase that has demonstrated efficacy in ran-
domized double-blind phase III trials of the treatment Case Presentation
of advanced NSCLC [2,3]. The side effect profile of
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