原创力文档atypical primary meningioma in the nasal septum with malignant transformation and distant metastasis主要非典型脑膜瘤与恶性鼻中隔转换和远处转移.pdfVIP
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atypical primary meningioma in the nasal septum with malignant transformation and distant metastasis主要非典型脑膜瘤与恶性鼻中隔转换和远处转移
Baek et al. BMC Cancer 2012, 12:275
/1471-2407/12/275
CASE REPORT Open Access
Atypical primary meningioma in the nasal septum
with malignant transformation and distant
metastasis
1* 1 1 2 3
Byoung Joon Baek , Jae–Min Shin , Chi Kyou Lee , Ji Hye Lee and Koen Hyeong Lee
Abstract
Background: Primary extracranial meningiomas (PEMs) originating from the nasal septum are extremely rare, as are
extracranial metastases of meningiomas.
Case presentation: A 44-year-old male presented with a 2-month history of left-side nasal obstruction and
frequent episodes of epistaxis. A friable mass originating from the nasal septum was resected completely via an
endoscopic endonasal approach. According to WHO criteria, the tumor was diagnosed as an atypical meningioma
radiologically and histopathologically. Two years later, a tumor recurred at the primary site with the same
histopathological findings, and the patient was given local external radiotherapy (6840 cGy in 38 fractions). Two
months after this local recurrence, a left anterior chest wall mass and a left parietal area scalp mass were observed.
The subcutaneous mass was resected and showed histological evidence of malignant transformation. Several
months after the last operation, the patient died.
Conclusions: We describe the clinical, radiological, and bio-pathological features of this unique case and review the
literature on atypical PEMs originating in the nasal septum. To our knowledge, this is the first reported case of an
atypical PEM originating from the nasal septum that recurred with malignant transformation and extracranial
metastasis.
Keywords: Extracranial meningiomas, Ectopic meningiomas, Atypical meningiomas, Nasal septum, Nasal cavity,
M
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