原创力文档automation of gene assignments to metabolic pathways using high-throughput expression data自动化作业代谢途径使用高通量基因表达数据.pdfVIP
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automation of gene assignments to metabolic pathways using high-throughput expression data自动化作业代谢途径使用高通量基因表达数据
BMC Bioinformatics BioMed Central
Methodology article Open Access
Automation of gene assignments to metabolic pathways using
high-throughput expression data
Liviu Popescu and Golan Yona*
Address: Department of Computer Science, Cornell University, Ithaca, NY
Email: Liviu Popescu - liviup@; Golan Yona* - golan@
* Corresponding author
Published: 31 August 2005 Received: 18 July 2005
Accepted: 31 August 2005
BMC Bioinformatics 2005, 6:217 doi:10.1186/1471-2105-6-217
This article is available from: /1471-2105/6/217
© 2005 Popescu and Yona; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Accurate assignment of genes to pathways is essential in order to understand the
functional role of genes and to map the existing pathways in a given genome. Existing algorithms
predict pathways by extrapolating experimental data in one organism to other organisms for which
this data is not available. However, current systems classify all genes that belong to a specific EC
family to all the pathways that contain the corresponding enzymatic reaction, and thus introduce
ambiguity.
Results: Here we describe an algorithm for assignment of genes to cellular pathways that
addresses this problem by selectively
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