原创力文档evaluation of the soft tissue biocompatibility of mgca0.8 and surgical steel 316l in vivo a comparative study in rabbits软组织生物相容性评价mgca0.8和手术钢316 l体内兔子的比较研究.pdfVIP
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evaluation of the soft tissue biocompatibility of mgca0.8 and surgical steel 316l in vivo a comparative study in rabbits软组织生物相容性评价mgca0.8和手术钢316 l体内兔子的比较研究
Erdmann et al. BioMedical Engineering OnLine 2010, 9:63
/content/9/1/63
RESEARCH Open Access
Evaluation of the soft tissue biocompatibility of
MgCa0.8 and surgical steel 316L in vivo: a
comparative study in rabbits
1* 1 2 1 1
Nina Erdmann , Alexandr Bondarenko , Marion Hewicker-Trautwein , Nina Angrisani , Janin Reifenrath ,
Arne Lucas3, Andrea Meyer-Lindenberg1
* Correspondence: nina. Abstract
erdmann@tiho-hannover.de
1Small Animal Clinic, University of Background: Recent studies have shown the potential suitability of magnesium
Veterinary Medicine Hannover,
Bünteweg 9, 30559 Hannover, alloys as biodegradable implants. The aim of the present study was to compare the
Germany soft tissue biocompatibility of MgCa0.8 and commonly used surgical steel in vivo.
Methods: A biodegradable magnesium calcium alloy (MgCa0.8) and surgical steel
(S316L), as a control, were investigated. Screws of identical geometrical conformation
were implanted into the tibiae of 40 rabbits for a postoperative follow up of two,
four, six and eight weeks. The tibialis cranialis muscle was in direct vicinity of the
screw head and thus embedded in paraffin and histologically and
immunohistochemically assessed. Haematoxylin and eosin staining was performed to
identify macrophages, giant cells and heterophil granulocytes as well as the extent of
tissue fibrosis and necrosis. Mouse anti-CD79a and
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