hiv-1 subtype distribution in morocco based on national sentinel surveillance data 2004-2005hiv - 1亚型分布在摩洛哥基于国家哨点监测数据2004 - 2005.pdfVIP

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hiv-1 subtype distribution in morocco based on national sentinel surveillance data 2004-2005hiv - 1亚型分布在摩洛哥基于国家哨点监测数据2004 - 2005.pdf

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hiv-1 subtype distribution in morocco based on national sentinel surveillance data 2004-2005hiv - 1亚型分布在摩洛哥基于国家哨点监测数据2004 - 2005

Akrim et al. AIDS Research and Therapy 2012, 9:5 /content/9/1/5 RESEARCH Open Access HIV-1 Subtype distribution in morocco based on national sentinel surveillance data 2004-2005 1 1 2 3 4 5* Mohammed Akrim , Sanae Lemrabet , Elmir Elharti , Rebecca R Gray , Jean Claude Tardy , Robert L Cook , 6 4 5 1,2 Marco Salemi , Patrice Andre , Taj Azarian and Rajae El Aouad Abstract Background: Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey. Results: While subtype B is still the most prevalent, 23.3% of samples represented non-B subtypes, the majority of which were classified as CRF02_AG (15%). Molecular clock analysis confirmed that the initial introduction of HIV-1B in Morocco probably came from Europe in the early 1980s. In contrast, the CRF02_AG strain appeared to be introduced from sub-Saharan Africa in two separate events in the 1990s. Conclusions: Subtype CRF02_AG has been emerging in Morocco since the 1990s. More information about the factors introducing HIV subtype-specific transmission will inform the prevention strategy in the region. Keywords: HIV-1, subtypes, phylogeny, Morocco Introduction where they are most prevalent [8,9]. The increasing HIV-1 variability remains a formidable challenge for diversity of HIV-1 underscores the need for diagnostics