hormonal responses upon return of spontaneous circulation after cardiac arrest a retrospective cohort study荷尔蒙反应在心脏骤停后自发循环回顾性队列研究.pdfVIP
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hormonal responses upon return of spontaneous circulation after cardiac arrest a retrospective cohort study荷尔蒙反应在心脏骤停后自发循环回顾性队列研究
Kim et al. Critical Care 2011, 15:R53
/content/15/1/R53
RESEARCH Open Access
Hormonal responses upon return of spontaneous
circulation after cardiac arrest: a retrospective
cohort study
1 2* 3 1 4 1
Jin Joo Kim , Sung Youl Hyun , Seong Youn Hwang , Young Bo Jung , Jong Hwan Shin , Yong Su Lim ,
1 1 1
Jin Seong Cho , Hyuk Jun Yang , Gun Lee
Abstract
Introduction: Cardiac arrest is often fatal and can be extremely stressful to patients, even if spontaneous rhythm is
returned. The purpose of this study was to analyze the hormonal response after return of spontaneous circulation (ROSC).
Methods: This is a retrospective review of the chart and laboratory findings in a single medical facility. The
patients admitted to the intensive care unit after successful resuscitation after out-of-hospital cardiac arrest were
retrospectively identified and evaluated. Patients with hormonal diseases, patients who received cortisol treatment,
those experiencing trauma, and pregnant women were excluded. Serum cortisol, adrenocorticotropic hormone
(ACTH), and anti-diuretic hormone (ADH (vasopressin)) were analyzed and a corticotropin-stimulation test was
performed. Mortality at one week and one month after admission, and neurologic outcome (cerebral performance
category (CPC)) one month after admission were evaluated.
Results: A total of 117 patients, including 84 males (71.8%), were evaluated in this study. One week and one month
after admission, 87 (74.4%) and 65 patients (55.6%) survived, respectively. Relative adrenal insufficiency, and higher
plasma ACTH and ADH levels were associated with shock-related mortality (P = 0.046, 0.005, and 0.037, respectiv
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