intracerebroventricular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake ratintracerebroventricular管理β-protein淀粉样蛋白寡聚物选择性增加清醒大鼠背侧海马透析液谷氨酸水平.pdfVIP

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intracerebroventricular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake ratintracerebroventricular管理β-protein淀粉样蛋白寡聚物选择性增加清醒大鼠背侧海马透析液谷氨酸水平.pdf

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intracerebroventricular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake ratintracerebroventricular管理β-protein淀粉样蛋白寡聚物选择性增加清醒大鼠背侧海马透析液谷氨酸水平

Sensors 2008, 8, 7428-7437; DOI: 10.3390/s8117428 OPEN ACCESS sensors ISSN 1424-8220 /journal/sensors Article Intracerebroventricular Administration of Amyloid -protein Oligomers Selectively Increases Dorsal Hippocampal Dialysate Glutamate Levels in the Awake Rat 1 2 1 1 Sean D. O’Shea , Imelda M. Smith , Olive M. McCabe , Michelle M. Cronin , Dominic M. Walsh 2 and William T. O’Connor 1, 3, 4,* 1 Applied Neurotherapeutics Research Group, Conway Institute, University College Dublin, Dublin 4, Ireland 2 Laboratory for Neurodegenerative Research, Conway Institute, University College Dublin, Dublin 4, Ireland; E-mail: dominic.walsh@ucd.ie 3 Graduate Medical School, University of Limerick, Limerick, Ireland; E-mail: william.oconnor@ul.ie 4 Materials and Surface Science Institute, University of Limerick, Limerick, Ireland * Author to whom correspondence should be addressed; E-mails: william.oconnor@ul.ie (D. M. W.); dominic.walsh@ucd.ie (W. T. O.) Received: 9 July 2008; in revised form: 10 November 2008 / Accepted: 11 November 2008 / Published: 19 November 2008 Abstract: Extensive evidence supports an important role for soluble oligomers of the amyloid -protein (A) in Alzheimer’s Disease pathogenesis. In the present study we combined intracerebroventricular (icv) injections with brain microdialysis technology in the fully conscious rat to assess the effects of ic