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how does infliximab work in rheumatoid arthritis英夫利昔单抗类风湿性关节炎工作如何
Arthritis Research Vol 4 Suppl 2 Maini and Feldmann
How does infliximab work in rheumatoid arthritis?
Ravinder N Maini and Marc Feldmann
The Kennedy Institute of Rheumatology Division, Imperial College of Science Technology and Medicine, London, UK
Correspondence: Ravinder N. Maini, FRCP, The Kennedy Institute of Rheumatology Division, Imperial College of Science Technology and Medicine,
1 Aspenlea Road, London, W6 8LH, UK. Tel: +44(0)20 8383 4403; fax: +44(0)20 8748 3293; e-mail: r.maini@ic.ac.uk
Received: 31 October 2001 Arthritis Res 2002, 4 (suppl 2):S22-S28
Accepted: 6 November 2001 © 2002 BioMed Central Ltd
Published: 27 March 2002 (Print ISSN 1465-9905; Online ISSN 1465-9913)
Abstract
Since the initial characterization of tumor necrosis factor alpha (TNFα), it has become clear that TNFα
has diverse biologic activity. The realization that TNFα plays a role in rheumatoid arthritis (RA) has led
to the development of anti-TNF agents for the treatment of RA. Infliximab, a chimeric monoclonal
antibody that specifically, and with high affinity, binds to TNFα and neutralizes the cytokine, is currently
approved for the treatment of RA and Crohn’s disease, another immune-inflammatory disorder. In
addition to establishing the safety and efficacy of infliximab, clinical research has also provided insights
into the complex cellular and cytokine-dependent pathways involved in the pathophysiology of RA,
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