how flaviviruses activate and suppress the interferon response黄病毒激活和抑制干扰素的反应如何.pdfVIP

Viruses 2010, 2, 676-691; doi:10.3390/v2020676 OPEN ACCESS Viruses ISSN 1999-4915 /journal/viruses Review How Flaviviruses Activate and Suppress the Interferon Response Jorge L. Muñoz-Jordán 1,* and Brenda L. Fredericksen 2 1 Molecular Diagnostics and Research Laboratory, Centers for Disease Control and Prevention, Division of Vector Borne Infectious Diseases, Dengue Branch, 1324 Calle Cañada, San Juan, PR 00920, Puerto Rico 2 Department of Cell Biology and Molecular Genetics and Maryland Pathogen Research Institute, University of Maryland, MD 20742, USA; E-Mail: bfreder@ * Author to whom correspondence should be addressed; E-Mail: ckq2@; Tel.: +1-787-2873728; Fax: +1-787-706-2496. Received: 24 November 2009; in revised form: 4 February 2010 / Accepted: 4 February 2010 / Published: 23 February 2010 Abstract: The flavivirus genus includes viruses with a remarkable ability to produce disease on a large scale. The expansion and increased endemicity of dengue and West Nile viruses in the Americas exemplifies their medical and epidemiological importance. The rapid detection of viral infection and induction of the innate antiviral response are crucial to determining the outcome of infection. The intracellular pathogen receptors RIG-I and MDA5 play a central role in detecting flavivirus infections and initiating a robust antiviral response. Yet, these viruses are still capable of producing acute illness in humans. It is now clear that flaviviruses utilize a variet