原创力文档high-altitude physiology and pathophysiology implications and relevance for intensive care medicine高空重症监护医学生理学和病理生理学的影响和相关性.pdfVIP
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high-altitude physiology and pathophysiology implications and relevance for intensive care medicine高空重症监护医学生理学和病理生理学的影响和相关性
Available online /content/11/1/203
Review
High-altitude physiology and pathophysiology:
implications and relevance for intensive care medicine
Michael Grocott, Hugh Montgomery and Andre Vercueil
Centre for Altitude, Space and Extreme Environment Medicine (CASE Medicine), UCL Institute of Human Health and Performance, Ground Floor,
Charterhouse Building, UCL Archway Campus, Highgate Hill, London, N19 5LW, UK
Corresponding author: Michael Grocott, mike.grocott@ucl.ac.uk
Published: 1 February 2007 Critical Care 2007, 11:203 (doi:10.1186/cc5142)
This article is online at /content/11/1/203
© 2007 BioMed Central Ltd
Abstract inflammatory response, further perpetuating the cascade of
Cellular hypoxia is a fundamental mechanism of injury in the critical illness. Furthermore, myocardial tissue hypoxia may
critically ill. The study of human responses to hypoxia occurring as impair contractile function, thus reducing the total blood flow
a consequence of hypobaria defines the fields of high-altitude and further exacerbating global tissue hypoxia [3].
medicine and physiology. A new paradigm suggests that the
physiological and pathophysiological responses to extreme Responses to continued hypoxaemia and tissue hypoxia may
environmental challenges (for example, hypobaric hypoxia, hyper-
prove detrimental in the long term. For example, in Monge’s
baria, microgravity, cold, heat) may be similar to responses seen in
critical illness. The present review explores the idea that human disease (chronic m
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