high-efficiency gene transfer into nontransformed cells utility for studying gene regulation and analysis of potential therapeutic targets高效基因转移成是非细胞效用为研究基因调控和分析潜在的治疗靶点.pdfVIP

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high-efficiency gene transfer into nontransformed cells utility for studying gene regulation and analysis of potential therapeutic targets高效基因转移成是非细胞效用为研究基因调控和分析潜在的治疗靶点.pdf

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high-efficiency gene transfer into nontransformed cells utility for studying gene regulation and analysis of potential therapeutic targets高效基因转移成是非细胞效用为研究基因调控和分析潜在的治疗靶点

Available online /content/4/S3/S215 Supplement Review High-efficiency gene transfer into nontransformed cells: utility for studying gene regulation and analysis of potential therapeutic targets Nicole J Horwood, Clive Smith, Evangelos Andreakos, Emilia Quattrocchi, Fionula M Brennan, Marc Feldmann and Brian MJ Foxwell Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, London, UK Correspondence: Brian MJ Foxwell, Kennedy Institute of Rheumatology Division, Imperial College Faculty of Medicine, Charing Cross Campus, ARC Building, 1 Aspenlea Road, London, UK. Tel: +44 (0)20 8383 4444; fax: +44 (0)20 8563 0399; e-mail: b.foxwell@ic.ac.uk Received: 22 January Arthritis Res 2002, 4 (suppl 3):S215-S225 Revisions requested: 23 January 2002 This article may contain supplementary data which can only be found Revisions received: 14 February 2002 online at /content/4/S3/S215 Accepted: 3 March 2002 © 2002 BioMed Central Ltd Published: 9 May 2002 (Print ISSN 1465-9905; Online ISSN 1465-9913) Chapter summary The elucidation of the signalling pathways involved in inflammatory diseases, such as rheumatoid arthritis, could provide long sought after targets for therapeutic intervention. Gene regulation is complex and varies depending on the cell type, as well as the signal eliciting gene activation. However, cells from certain lineages, such as macrophages, are specialised to degrade exogenous material and consequently do not easily transfect. Methods for high-efficiency g