high-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis a case report高剂量布洛芬治疗与食管溃疡在囊性纤维化患者肺切除术后一个案例报告.pdfVIP

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high-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis a case report高剂量布洛芬治疗与食管溃疡在囊性纤维化患者肺切除术后一个案例报告.pdf

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high-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis a case report高剂量布洛芬治疗与食管溃疡在囊性纤维化患者肺切除术后一个案例报告

BMC Pediatrics BioMed Central Case report Open Access High-dose ibuprofen therapy associated with esophageal ulceration after pneumonectomy in a patient with cystic fibrosis: a case report Jennifer E Mackey and Ran D Anbar* Address: Department of Pediatrics, University Hospital, State University of New York Upstate Medical University, Syracuse, NY, USA Email: Jennifer E Mackey - mackeyj@; Ran D Anbar* - anbarr@ * Corresponding author Published: 13 September 2004 Received: 26 May 2004 Accepted: 13 September 2004 BMC Pediatrics 2004, 4:19 doi:10.1186/1471-2431-4-19 This article is available from: /1471-2431/4/19 © 2004 Mackey and Anbar; licensee BioMed Central Ltd. This is an open-access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. cystic fibrosisesophageal ulcerationgastrointestinal bleedibuprofenpneumonectomy Abstract Background: Lung disease in patients with cystic fibrosis is thought to develop as a result of airway inflammation, infection, and obstruction. Pulmonary therapies for cystic fibrosis that reduce airway inflammation include corticosteroids, rhDNase, antibiotics, and high-dose ibuprofen. Despite evidence that high-dose ibuprofen slows the progression of lung disease in patients with cystic fibrosis, many clinicians have chosen not to use this therapy because of concerns regardin