high-frequency irreversible electroporation (h-fire) for non-thermal ablation without muscle contraction高频不可逆电穿孔(h-fire)非热能的消融没有肌肉收缩.pdfVIP

High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction Arena et al. Arena et al. BioMedical Engineering OnLine 2011, 10:102 /content/10/1/102 (21 November 2011) Arena et al. BioMedical Engineering OnLine 2011, 10:102 /content/10/1/102 RESEARCH Open Access High-frequency irreversible electroporation (H-FIRE) for non-thermal ablation without muscle contraction 1 1 2 3 1 Christopher B Arena , Michael B Sano , John H Rossmeisl Jr , John L Caldwell , Paulo A Garcia , Marissa Nichole Rylander4 and Rafael V Davalos1* * Correspondence: davalos@ Abstract 1Bioelectromechanical Systems Lab, Virginia Tech-Wake Forest Background: Therapeutic irreversible electroporation (IRE) is an emerging University School of Biomedical Engineering and Sciences, 330 technology for the non-thermal ablation of tumors. The technique involves ICTAS Building (MC0298), delivering a series of unipolar electric pulses to permanently destabilize the plasma Blacksburg, VA. 24061, USA membrane of cancer cells through an increase in transmembrane potential, which Full list of author information is available at the end of the article leads to the development of a tissue lesion. Clinically, IRE requires the administration of paralytic agents to prevent muscle contractions during treatment that are associated with the delivery of electric pulses. This study shows that by applying high-frequency, bipolar bursts, muscle contractions can be el