highly efficient esterification of ferulic acid under microwave irradiation高效微波辐照下阿魏酸的酯化.pdfVIP

Molecules 2009, 14, 2118-2126; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Highly Efficient Esterification of Ferulic Acid Under Microwave Irradiation Nian-Guang Li 1,3, Zhi-Hao Shi 2, Yu-Ping Tang 1,*, Bao-Quan Li 1 and Jin-Ao Duan 1,* 1 Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China; E-mails: linianguang@163.com (N-G.L.); libaoquan121@163.com (B-Q.L.) 2 Division of Organic Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 211198, China; E-mail: sszh163@163.com (Z-H.S.) 3 Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, China * Authors to whom correspondence should be addressed; E-mails: yupingtang@ (Y-P.T.), dja@ (J-A.D.); Tel.: +86-25 Fax: +86-25 Received: 14 May 2009; in revised form: 30 May 2009 / Accepted: 8 June 2009 / Published: 10 June 2009 Abstract: A highly efficient synthesis of alkyl ferulates under microwave irradiation is described. The time of these reactions ranged from 3 to 5 minutes, which was much shorter than the traditional synthetic methods, and the alkyl ferulates were obtained in higher yields. Keywords: esterification; ferulic acid; microwave irradiation; highly efficient 1. Introduction It is well established that under normal conditions, there is a steady state balance between pro- oxidants and antioxidants, which is ne