highly efficient and reusable copper-catalyzed n-arylation of nitrogen-containing heterocycles with aryl halides氮含量的高效和可重用copper-catalyzed n-arylation杂环化合物与芳基卤化物.pdfVIP

Molecules 2009, 14, 5169-5178; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Communication Highly Efficient and Reusable Copper-Catalyzed N-Arylation of Nitrogen-Containing Heterocycles with Aryl Halides 1 1 2 1 1 2 A Young Kim , Hyun Ju Lee , Ji Chan Park , Hyunju Kang , Haesik Yang , Hyunjoon Song and Kang Hyun Park 1,* 1 Department of Chemistry and Chemistry Institute for Functional Materials, Pusan National University, Busan 609-735, Korea; E-Mails: cuteangel02@ (AY.K.); hjloveth486@ (H.J.L.); asteria818@ (H.K.); hyang@pusan.ac.kr (H.Y.) 2 Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Korea; E-Mails: whiteprince@kaist.ac.kr (J.C.P.); hsong@kaist.ac.kr (H.S.) * Author to whom correspondence should be addressed; E-Mail: chemistry@pusan.ac.kr. Received: 10 November 2009; in revised form: 4 December 2009 / Accepted: 9 December 2009 / Published: 10 December 2009 Abstract: CuO/AB was found to be a simple and efficient catalyst for the N-arylation of a variety of nitrogen-containing heterocycles, giving the products in excellent yields. Keywords: N-arylation; copper; heterocycles; heterogeneous catalyst; acetylene black 1. Introduction The copper-mediated C-heteroatom (C-N, C-O, C-S, C-P, C-Se), C-C, and C-metal bonds formations are pivotal transformations that have been developed to include a wide range of substrates. Specifically