high synovial expression of the inhibitory fcγriib in rheumatoid arthritis高的滑膜表达抑制fcγriib风湿性关节炎.pdfVIP

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high synovial expression of the inhibitory fcγriib in rheumatoid arthritis高的滑膜表达抑制fcγriib风湿性关节炎.pdf

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high synovial expression of the inhibitory fcγriib in rheumatoid arthritis高的滑膜表达抑制fcγriib风湿性关节炎

Available online /content/9/3/R51 Vol 9 No 3 Open Access Research article High synovial expression of the inhibitory FcγRIIb in rheumatoid arthritis 1 2 3 2 1 Sofia E Magnusson , Marianne Engström , Uwe Jacob , Ann-Kristin Ulfgren and Sandra Kleinau 1Department of Cell and Molecular Biology, Programme for Molecular Immunology, Uppsala University, Husargatan 3, Uppsala, 751 24, Sweden 2Department of Medicine, Rheumatology Research Unit, Karolinska University Hospital Solna, Stockholm, 171 76, Sweden 3SuppreMol, Am Klopferspitz 19, Martinsried, 821 52, Germany Corresponding author: Sandra Kleinau, sandra.kleinau@icm.uu.se Received: 14 Mar 2007 Revisions requested: 24 Apr 2007 Revisions received: 8 May 2007 Accepted: 23 May 2007 Published: 23 May 2007 Arthritis Research Therapy 2007, 9:R51 (doi:10.1186/ar2206) This article is online at: /content/9/3/R51 © 2007 Magnusson et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Activating Fc gamma receptors (FcγRs) have been identified as all activating FcγRs were expressed and significantly up- having important roles in the inflammatory joint reaction in regulated in RA, regardless of disease duration. Macrophages rheumatoid arthritis (RA) and murine models of arthritis. were one of the major cell types in the RA synovium expressing However, the role of the inhibitory FcγRIIb in the regulation of the