原创力文档high throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules高吞吐量萃取的植物、海洋和真菌标本保存的生物活性分子.pdfVIP
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high throughput extraction of plant, marine and fungal specimens for preservation of biologically active molecules高吞吐量萃取的植物、海洋和真菌标本保存的生物活性分子
Molecules 2010, 15, 4526-4563; doi:10.3390/molecules
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Review
High Throughput Extraction of Plant, Marine and Fungal
Specimens for Preservation of Biologically Active Molecules
Thomas G. McCloud
Natural Products Support Group, Applied/Developmental Research Support Program, SAIC-Frederick,
Inc., NCI-Frederick, Frederick, MD 21702, USA; E-Mail: tm200p@; Tel.: +1-301-8467277;
Fax: +1-301-8465206.
Received: 6 May 2010; in revised form: 17 June 2010 / Accepted: 21 June 2010 /
Published: 24 June 2010
Abstract: The Developmental Therapeutics Program (DTP) of the U.S. National Cancer
Institute (NCI), at its NCI-Frederick facility, has built perhaps the largest and most diverse
natural products screening library in the world for drug discovery. Composed of plant,
marine organism and microbial extracts, it currently contains in excess of 230,000 unique
materials. From the inception of this program to identify new anticancer chemotherapeutics
from natural products sources in 1987, two extracts have been sequentially prepared from
each specimen: one produced by organic solvent extraction, which yields a complex
material that contains non- to moderately polar small molecules, and a water-soluble
extract, a milieu largely unexplored for useful drugs in earlier years, which contains polar
small to medium-sized molecules. Plant specimens and microbial ferments are extracted by
modified traditional methods, while the method developed
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