原创力文档high virologic response rate after second-line boosted protease inhibitor-based antiretroviral therapy regimens in children from a resource limited setting病毒学反应率高后二线提高蛋白酶inhibitor-based儿童的抗逆转录病毒治疗方案从一个资源有限的设置.pdfVIP
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high virologic response rate after second-line boosted protease inhibitor-based antiretroviral therapy regimens in children from a resource limited setting病毒学反应率高后二线提高蛋白酶inhibitor-based儿童的抗逆转录病毒治疗方案从一个资源有限的设置
Puthanakit et al. AIDS Research and Therapy 2012, 9:20
/content/9/1/20
RESEARCH Open Access
High virologic response rate after second-line
boosted protease inhibitor-based antiretroviral
therapy regimens in children from a resource
limited setting
1,2 3 4 5
Thanyawee Puthanakit , Gonzague Jourdain , Piyarat Suntarattiwong , Kulkanya Chokephaibulkit ,
1 1 1,5 6 7
Umaporn Siangphoe , Tulathip Suwanlerk , Wasana Prasitsuebsai , Virat Sirisanthana , Pope Kosalaraksa ,
8 9 4 1,10,11*
Witaya Petdachai , Rawiwan Hansudewechakul , Naris Waranawat and Jintanat Ananworanich On behalf of
the HIV-NAT 086 study team
Abstract
Background: Limited data exist for the efficacy of second-line antiretroviral therapy among children in resource
limited settings. We assessed the virologic response to protease inhibitor-based ART after failing first-line non-
nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens.
Methods: A retrospective chart review was conducted at 8 Thai sites of children who switched to PI –based
regimens due to failure of NNRTI –based regimens. Primary endpoints were HIV RNA 400 copies/ml and CD4
change over 48 weeks.
Results: Data from 241 children with median baseline values before starting PI-based regimens of 9.1 years for age,
10% for CD4%, and 4.8 log10 copies/ml for HIV RNA were included; 104 (41%) received a single ritonavir-boosted PI
(sbPI) with 2 NRTIs and 137
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