how echinoccocosis affects potential cancer markers in plasma galectin-3, sn-cadherin and se-cadherin a preliminary reportechinoccocosis如何影响潜在的癌症标记物等离子galectin-3 sn-cadherin se-cadherin初步报告.pdfVIP

Giebultowicz et al. Diagnostic Pathology 2012, 7:17 /content/7/1/17 RESEARCH Open Access How echinoccocosis affects potential cancer markers in plasma: galectin-3, sN-cadherin and sE-cadherin? A preliminary report 1* 2 1 3 2 Joanna Giebultowicz , Malgorzata Polanska-Plachta , Piotr Wroczynski , Piotr Zaborowski and Jerzy A Polanski Abstract Background: An increasing number of publications are suggesting that galectin-3 (Gal-3) and soluble cadherin fragments, such as E-cadherin (sE-CAD) and N-cadherin (sN-CAD), may be considered as cancer markers. Despite the promising results of the studies, there are no data concerning their levels in the plasma of echinococcosis patients. In most cases, echinoccocosis affects the liver, and its symptoms and disease course are very similar to those of liver cancer. The aim of the present study was to observe whether echinococcosis affects the concentration of soluble sN-CAD, sE-CAD fragments and Gal-3 in plasma and to determine which of them could be considered reliable liver cancer markers for further research. Methods: The concentrations of sN-CAD, sE-CAD and Gal-3 in the EDTA plasma of patients suffering from echinococcosis (N = 20), liver cancers (N = 10) and healthy subjects (N = 20) were measured using the ELISA method. Results: The plasma concentration of sE-CAD was lower (p = 0.0381), and that of Gal-3 higher (p = 0.0288), in echinococcosis than in the healthy group. However, only the concentration of sE-CAD differed significantly among the three analysed groups. In echinococcosis there was a correlation between the sE-CAD and CRP levels (rs = 0.79; p = 0.0066) as well as a correlation between the sE-CAD level and