intracellular localization and cellular factors interaction of htlv-1 and htlv-2 tax proteins similarities and functional differences细胞内定位和细胞因子相互作用的htlv 1和htlv-2税收蛋白质相似和功能不同.pdfVIP

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intracellular localization and cellular factors interaction of htlv-1 and htlv-2 tax proteins similarities and functional differences细胞内定位和细胞因子相互作用的htlv 1和htlv-2税收蛋白质相似和功能不同.pdf

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intracellular localization and cellular factors interaction of htlv-1 and htlv-2 tax proteins similarities and functional differences细胞内定位和细胞因子相互作用的htlv 1和htlv-2税收蛋白质相似和功能不同

Viruses 2011, 3, 541-560; doi:10.3390/v3050541 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences Umberto Bertazzoni 1,*, Marco Turci 1, Francesca Avesani 1, Gianfranco Di Gennaro 1, Carlo Bidoia 2, Maria Grazia Romanelli 1,* 1 Department of Life and Reproduction Sciences, University of Verona, Strada le Grazie 8, 37134, Verona, Italy; E-Mails: marco.turci@univr.it (M.T.); francesca.avesani@ (F.A.); gianfranco.digennato@univr.it (G.D.G.) 2 Centre for Research in Infectious Diseases, University College Dublin, Belfield, Dublin 4, Ireland; E-Mail: carlo.bidoia@ucd.ie (C.B.) * Authors to whom correspondence should be addressed; E-Mails: umberto.bertazzoni@univr.it (U.B.); mariagrazia.romanelli@univr.it (M.G.R); Tel.: +39-0458027182; Fax: +390458027180. Received: 26 March 2011 / Accepted: 26 April 2011 / Published: 9 May 2011 Abstract: Human T-lymphotropic viruses type 1 (HTLV-1) and type 2 (HTLV-2) present very similar genomic structures but HTLV-1 is more pathogenic than HTLV-2. Is this difference due to their transactivating Tax proteins, Tax-1 and Tax-2, which are responsible for viral and cellular gene activation? Do Tax-1 and Tax-2 differ in their cellular localization and in their interaction pattern with cellular factors? In this review, we summarize Tax-1 and Tax-2 structural and phenotypic propert