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intraindividual variability (iiv) in an animal model of adhd - the spontaneously hypertensive rat个体内的可变性(iiv)多动症u2014u2014自发性高血压大鼠的动物模型
Perry et al. Behavioral and Brain Functions 2010, 6:56
/content/6/1/56
RESEARCH Open Access
Intraindividual variability (IIV) in an animal model
of ADHD - the Spontaneously Hypertensive Rat
1* 2 3,4
Guy ML Perry , Terje Sagvolden , Stephen V Faraone
Abstract
Attention-deficit/hyperactivity disorder (ADHD) is characterized by numerous behaviors including inattention,
hyperactivity and impulsiveness. ADHD-affected individuals also have high intra-individual variability (IIV) in reaction
time. The genetic control of IIV is not well understood. The single study of the genetics of this phenomenon in
humans detected only marginal associations between genotypes at two candidate genes for ADHD and variability
in response time. The Spontaneously Hypertensive Rat (SHR/NCrl) is an animal model of ADHD, expressing high
activity, inattention and impulsive behavior during operant and task tests. The SHR might be useful for identifying
genes for variability, but it is not known whether it also expresses high IIV, as is symptomatic of ADHD. We there-
fore conducted an investigation of IIV in the SHR. We used 16 SHR/NCrl rats and 15 Wistar-Kyoto (WKY/Nico) con-
trols applying a reinforcement schedule used in the validation of the SHR as an animal model of ADHD. We
represented IIV as the average absolute deviation of individual behavior within the five 18-min segments of each
experimental session from the average behavioral trait value within that session (’individual phenotypic dispersion’,
PD ). PD for hyperactivity, impulsiveness and inattention in the SHR and WKY rats was analyzed using nonpara-
i i
metric ranking by experimental session. SHR/NCrl rats had higher PDi than WKY/Nico controls for impulsiveness
and inattention. Th
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