monoterpenoid indole alkaloids from alstonia yunnanensis and their cytotoxic and anti-inflammatory activities从alstonia monoterpenoid吲哚生物碱将云南及其细胞毒性和抗炎活动.pdfVIP

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monoterpenoid indole alkaloids from alstonia yunnanensis and their cytotoxic and anti-inflammatory activities从alstonia monoterpenoid吲哚生物碱将云南及其细胞毒性和抗炎活动.pdf

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monoterpenoid indole alkaloids from alstonia yunnanensis and their cytotoxic and anti-inflammatory activities从alstonia monoterpenoid吲哚生物碱将云南及其细胞毒性和抗炎活动

Molecules 2012, 17, 13631-13641; doi:10.3390/molecules171113631 OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Monoterpenoid Indole Alkaloids from Alstonia yunnanensis and Their Cytotoxic and Anti-inflammatory Activities Peng Cao, Yong Liang, Xu Gao, Xiao-Ming Li, Zhen-Quan Song and Guobiao Liang * Department of Neurosurgery, Institue of Neurology, General Hospital of Shenyang Military Area Command, Shenyang Northern Hospital, #83 Wenhua Road, Shenhe District, Shenyang 110018, China * Author to whom correspondence should be addressed; E-Mail: sygbliang@; Tel.: +86-24-2889-7431, Fax: +86-24-2885-1230. Received: 12 October 2012; in revised form: 8 November 2012 / Accepted: 12 November 2012 / Published: 16 November 2012 Abstract: The 80% ethanol extract of Alstonia yunnanensis afforded five new monoterpenoid indole alkaloids: 11-hydroxy-6,7-epoxy-8-oxo-vincadifformine (1), 14-chloro-15-hydroxy- vincadifformine (2), perakine N -oxide (3), raucaffrinoline N -oxide (4), and vinorine 4 4 N ,N -dioxide (5), together with three known compounds: 11-methoxy-6,7-epoxy-8-oxo- 1 4 vincadifformine (6), vinorine N4-oxide (7) and vinorine (8). The structures of the isolated 1 1 compounds were established based on 1D and 2D ( H- H-COSY, HMQC, HMBC, and ROESY) NMR spectroscopy, in addition to high resolution