most nuclear systemic autoantigens are extremely disordered proteins implications for the etiology of systemic autoimmunity大多数核系统性自身抗原非常无序蛋白质对系统性自身免疫的病因学的影响.pdfVIP

Available online /content/7/6/R1360 Vol 7 No 6 Open Access Research article Most nuclear systemic autoantigens are extremely disordered proteins: implications for the etiology of systemic autoimmunity 1 2 3 Philip L Carl , Brenda RS Temple and Philip L Cohen 1Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA 2R. L. Juliano Structural Bioinformatics Core Facility, University of North Carolina, Chapel Hill, NC 27599, USA 3Division of Rheumatology, University of Pennsylvania School of Medicine and Philadelphia VA Medical Center, Philadelphia, PA 19104, USA Corresponding author: Philip L Carl, plc@ Received: 25 Apr 2005 Revisions requested: 2 Jun 2005 Revisions received: 4 Aug 2005 Accepted: 31 Aug 2005 Published: 6 Oct 2005 Arthritis Research Therapy 2005, 7:R1360-R1374 (DOI 10.1186/ar1832) This article is online at: /content/7/6/R1360 © 2005 Carl et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Patients with systemic autoimmune diseases usually produce model of epitope spreading that explains many of the high levels of antibodies to self-antigens (autoantigens). The paradoxical aspects of autoimmunity – in particular, the difficulty repertoire of common autoantigens is remarkably limited, yet no in identifying autoantigen-specific helper T cells that might readily understandable shared thread lin