murine coronavirus cell type dependent interaction with the type i interferon response小鼠冠状病毒细胞类型的依赖与i型干扰素的交互反应.pdfVIP

Viruses 2009, 1, 689-712; doi:10.3390/v1030689 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Murine Coronavirus Cell Type Dependent Interaction with the Type I Interferon Response Kristine M. Rose and Susan R. Weiss * Department of Microbiology, University of Pennsylvania, School of Medicine, 36th Street and Hamilton Walk, Philadelphia, PA 19104-60761, USA; E-Mail: rosekris@ * Author to whom correspondence should be addressed; E-Mail: weisssr@; Tel.: +1-215-898-8013; Fax: +1-215-573-4858. Received: 2 September 2009; in revised form: 30 October 2009 / Accepted: 4 November 2009 / Published: 4 November 2009 Abstract: Coronaviruses infect many species of animal including humans, causing acute and chronic diseases of many organ systems. Murine coronavirus, mouse hepatitis virus (MHV) infection of the mouse, provides animal models for the study of central nervous system disease, including encephalitis and demyelinating diseases such as Multiple Sclerosis and for hepatitis. While there are many studies of the adaptive immune response to MHV, there has until recently been scant information on the type I interferon (IFN) response to MHV. The relationship between MHV and the IFN-α/β response is paradoxical. While the type I IFN response is a crucial aspect of host defense against MHV in its natural host, there is little if any induction of IFN following infection of mouse fibroblast cell lines in vi