monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern sudan单核细胞和巨噬细胞和胎盘疟疾感染疟疾传播在苏丹东部地区不稳定.pdfVIP
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monocytes and macrophages and placental malaria infections in an area of unstable malaria transmission in eastern sudan单核细胞和巨噬细胞和胎盘疟疾感染疟疾传播在苏丹东部地区不稳定
Salih et al. Diagnostic Pathology 2011, 6:83
/content/6/1/83
RESEARCH Open Access
Monocytes and macrophages and placental
malaria infections in an area of unstable malaria
transmission in eastern Sudan
1 1 2 3 4
Magdi M Salih , Amal H Mohammed , Ahmed A Mohmmed , Gamal K Adam , Mustafa I Elbashir and
Ishag Adam4*
Abstract
Background: Maternal immunity is thought to play a major role in the increased susceptibility of pregnant women
to Plasmodium falciparum malaria. Few studies exist on immunohistochemical characterization of the placental
inflammatory infiltrate. The current study was conducted in Gadarif hospital in an area characterized by unstable
malaria transmission in eastern Sudan.
Method: Ninety three placentae were investigated for malaria histological changes and immunohistochemical
study for monocytes and macrophages (CD68).
Results: While 1(1.1%), 2(2.2%) and 20(21.5%) of the 93 placentae had acute, chronic and past malaria infections,
70(75.2%) had no malaria infections. Monocytes and macrophage (CD 68) were detected in 29 (31.2%) of these 93
placentae. Significantly higher rate of monocytes and macrophage were detected in placentae with malaria
infections [11/23 (47.8%) vs. 18/70 (25.7%); P = 0.047] especially in placentae with past malaria infections. Placental
malaria infections and monocytes and macrophages cells infiltration were not different between primiparae and
multiparae. There was no significant difference in the birth weight between the women with placental malaria
infections/monocytes and macrophages cells infiltration and those who had no placental malaria infections/cellular
infiltrations.
Conclusion: Significantly higher rate
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