nanoporous platforms for cellular sensing and delivery纳米多孔细胞传感和交付的平台.pdfVIP

Sensors 2002, 2, 111-120 sensors ISSN 1424-8220 © 2002 by MDPI /sensors Invited Paper Nanoporous Platforms for Cellular Sensing and Delivery 1 1 1,2,* Lara Leoni , Darlene Attiah and Tejal A. Desai 1Department of Bioengineering, University of Illinois at Chicago; 2Department of Biomedical Engineering, Boston University, 44 Cummington Street, Boston, MA 02215, USA. Tel: (617) 358- 3054. Fax: (617) 353-6766. * Author to whom correspondence should be addressed. E-mail: tdesai@ Received: 5 March 2002 / Accepted:19 March 2002 / Published: 20 March 2002 Abstract: In recent years, rapid advancements have been made in the biomedical applications of micro and nanotechnology. While the focus of such technology has primarily been on in vitro analytical and diagnostic tools, more recently, in vivo therapeutic and sensing applications have gained attention. This paper describes the creation of monodisperse nanoporous, biocompatible, silicon membranes as a platform for the delivery of cells. Studies described herein focus on the interaction of silicon based substrates with cells of interest in terms of viability, proliferation, and functionality. Such microfabricated nanoporous membranes can be used both in vitro for cell-based assays and in vivo for immunoisolation and drug delivery applications. Keywords: Nanotechnology, Drug delivery, Silicon, Immunoisolat